Article
HFE Cys282Tyr homozygotes with serum ferritin concentrations below 1000 microg/L are at low risk of hemochromatosis.
Hepatology (Baltimore, Md.) - 1 Sept 2010
Allen Katrina J, Bertalli Nadine A, Osborne Nicholas J, Constantine Clare C, Delatycki Martin B, Nisselle Amy E, Nicoll Amanda J, Gertig Dorota M, McLaren Christine E, Giles Graham G, Hopper John L, Anderson Gregory J, Olynyk John K, Powell Lawrie W, Gurrin Lyle C
Abstract excerpt
UNLABELLED: Hemochromatosis gene (HFE)-associated hereditary hemochromatosis (HH) is a genetic predisposition to iron overload and subsequent signs and symptoms of disease that potentially affects approximately 80,000 persons in Australia and almost 1 million persons in the United States. Most clinical cases are homozygous for the Cys282Tyr (C282Y) mutation in the HFE gene, with serum ferritin (SF) concentration...
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