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Article

Ferritin concentrations in synovial fluid are higher in osteoarthritis patients with HFE gene mutations (C282Y or H63D).

Scandinavian journal of rheumatology - 1 Jan 2010

Carroll G J, Sharma G, Upadhyay A, Jazayeri J A

Abstract excerpt

OBJECTIVES: In view of the clinical similarities between polyarticular osteoarthritis (POA) with metacarpophalangeal (MCP) joint involvement and the arthropathy that occurs in hereditary haemochromatosis (HH), it was hypothesized that osteochondral damage in both disorders may be due to localized iron overload. Accordingly, it was predicted that the concentration of ferritin in synovial fluid (SF) would be higher...

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Share to Ferritins
Share to Hemochromatosis Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Leukemia Inhibitory Factor

Share to Matrix Metalloproteinases

Share to Osteoarthritis, Knee

Share to Synovial Fluid

Share to Tissue Inhibitor of Metalloproteinase-1

Source

Identifiers

PMID: 20560808
DOI: 10.3109/03009741003677449

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ferritin concentrations in synovial fluid are higher in osteoarthritis patients with HFE gene mutations (C282Y or H63D).PMID 20560808Read ↗

Age-dependent ferritin elevations and HFE C282Y mutation as risk factors for symptomatic knee osteoarthritis in males: a longitudinal cohort study.Semantic proximity Read ↗

Primary osteoarthritis in the ankle joint is associated with finger metacarpophalangeal osteoarthritis and the H63D mutation in the HFE gene: evidence for a hemochromatosis-like polyarticular osteoarthritis phenotype.Semantic proximity Read ↗

Association of heterozygous hemochromatosis C282Y gene mutation with hand osteoarthritis.Semantic proximity Read ↗

HFE-related hemochromatosis: an update for the rheumatologist.Semantic proximity Read ↗

Osteoarthritis and analgesic consumption in haemochromatosis HFE C282Y homozygotes with normal or low iron parameters.Semantic proximity Read ↗

HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints.Semantic proximity Read ↗

Arthritis in hemochromatosis or iron storage disease.Semantic proximity Read ↗

Population-based study of the relationship between mutations in the hemochromatosis (HFE) gene and arthritis.Semantic proximity Read ↗

The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis.Semantic proximity Read ↗

Haemochromatosis genetic variants and musculoskeletal outcomes: 11.5 year follow-up in the UK Biobank cohort studySemantic proximity Read ↗

Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress.Semantic proximity Read ↗

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