Article
HFE C282Y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis.
Seminars in arthritis and rheumatism - 1 Jun 2012
Wang Yuanyuan, Gurrin Lyle C, Wluka Anita E, Bertalli Nadine A, Osborne Nicholas J, Delatycki Martin B, Giles Graham G, English Dallas R, Hopper John L, Simpson Julie A, Graves Stephen, Allen Katrina J, Cicuttini Flavia M
Abstract excerpt
OBJECTIVE: The evidence for an association between mutations in the HFE (hemochromatosis) gene and the risk of hip or knee osteoarthritis is inconsistent. Total joint replacement is considered a surrogate measure for symptomatic end-stage osteoarthritis. We examined the relationship between HFE gene mutations and risk of total hip and knee replacement using a prospective cohort study. METHODS: The Melbourne...
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