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Article

The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis.

Annals of the rheumatic diseases - 1 Nov 2007

Alizadeh B Z, Njajou O T, Hazes J M W, Hofman A, Slagboom P E, Pols H A P, van Duijn C M

Abstract excerpt

OBJECTIVES: To investigate the relation between the HFE C282Y and H63D variants with arthralgia and joint pathology in the population-based Rotterdam Study. METHODS: From a cohort of 7983 people aged 55 years and over, 2095 randomly drawn subjects were genotyped for C282Y and H63D variants. We compared the frequency of arthralgia, and the presence of chondrocalcinosis, osteophytes, joint space narrowing and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17284543
DOI: 10.1136/ard.2006.063099
PMCID: PMC2111641

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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