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Physical frailty, genetic predisposition, and type 2 diabetes mellitus.

Diabetes & metabolism - 1 Mar 2025

Xu Zhenyi, Lin Ruilang, Ji Xueying, Huang Chen, Wang Ce, Yu Yongfu, Bao Zhijun

Abstract excerpt

AIM: To examine the association between frailty and incident type 2 diabetes mellitus (T2DM), considering the joint effect of multimorbidity and genetic risk. METHODS: The study included 429,022 individuals in the UK Biobank. We used Cox regression with hazard ratio (HR) and 95 % confidence interval (CI) to 1) evaluate the associations of frailty with incident T2DM, 2) explore whether frailty and multimorbidity...

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PMID: 39900238
DOI: 10.1016/j.diabet.2025.101618

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