Article
Patterns of non-ARD variation in more than 300 full-length HLA-DPB1 alleles.
Human immunology - 1 Jan 2019
Klasberg Steffen, Lang Kathrin, Günther Marie, Schober Grit, Massalski Carolin, Schmidt Alexander H, Lange Vinzenz, Schöfl Gerhard
Abstract excerpt
Our understanding of sequence variation in the HLA-DPB1 gene is largely restricted to the hypervariable antigen recognition domain (ARD) encoded by exon 2. Here, we employed a redundant sequencing strategy combining long-read and short-read data to accurately phase and characterise in full length the majority of common and well-documented (CWD) DPB1 alleles as well as alleles with an observed frequency of at...
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