Regulation of HLA class I expression by non-coding gene variations.

doi:10.1371/journal.pgen.1010212

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Article

Regulation of HLA class I expression by non-coding gene variations.

PLoS genetics - 1 Jun 2022

Bettens Florence, Ongen Halit, Rey Guillaume, Buhler Stéphane, Calderin Sollet Zuleika, Dermitzakis Emmanouil, Villard Jean

Abstract excerpt

The Human Leukocyte Antigen (HLA) is a critical genetic system for different outcomes after solid organ and hematopoietic cell transplantation. Its polymorphism is usually determined by molecular technologies at the DNA level. A potential role of HLA allelic expression remains under investigation in the context of the allogenic immune response between donors and recipients. In this study, we quantified the...

Topics

Alleles
Gene Frequency
HLA Antigens
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
Haplotypes
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Humans
Leukocytes, Mononuclear

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Identifiers

PMID: 35666741
DOI: 10.1371/journal.pgen.1010212
PMCID: PMC9170083

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