Article
Regulation of HLA class I expression by non-coding gene variations.
PLoS genetics - 1 Jun 2022
Bettens Florence, Ongen Halit, Rey Guillaume, Buhler Stéphane, Calderin Sollet Zuleika, Dermitzakis Emmanouil, Villard Jean
Abstract excerpt
The Human Leukocyte Antigen (HLA) is a critical genetic system for different outcomes after solid organ and hematopoietic cell transplantation. Its polymorphism is usually determined by molecular technologies at the DNA level. A potential role of HLA allelic expression remains under investigation in the context of the allogenic immune response between donors and recipients. In this study, we quantified the...
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