A Simplified, Scalable Solution for Simultaneous Genotyping of Human Leukocyte Antigen Classical Class I and Human Platelet Antigen Genes Utilising Oxford Nanopore Technologies Long-Read Sequencing.

Abstract excerpt

Human leucocyte antigen (HLA) class I and human platelet antigens (HPAs) can elicit immune responses, leading to platelet transfusion refractoriness (PTRs). To support the clinical management of patients with PTR, transfusion of HLA class I and sometimes HPA-selected apheresis platelets is recommended. To facilitate this service, the HLA class I and HPA genotypes of platelet donors must be defined so that...

Topics

• Humans
• Antigens, Human Platelet
• Genotype
• Genotyping Techniques
• Histocompatibility Antigens Class I
• Platelet Transfusion
• Nanopore Sequencing
• High-Throughput Nucleotide Sequencing
• Genes, MHC Class I