Next-Generation Sequencing-Based High-Resolution Typing of HLA-A, -B, -C and HPA Genes in Jilin Province: Building a Platelet Donor Database and Identifying Novel Alleles.

doi:10.1111/tan.70851

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Next-Generation Sequencing-Based High-Resolution Typing of HLA-A, -B, -C and HPA Genes in Jilin Province: Building a Platelet Donor Database and Identifying Novel Alleles.

HLA - 1 Sept 2026

Han Yu, Yuan Hong, Yang Fan, Liu Lingling, Nie Tingting, Ju Ruiqing, Bai Rixin, Yu Jianghong, Wang Pengli, Jiao Lixin, Zhang Xuesong, Yan Li, Di Mei

Abstract excerpt

To systematically analyse HLA-A, -B and -C and human platelet antigen (HPA) genotypes of platelet donors in Jilin Province using next-generation sequencing (NGS) technology, a comprehensive donor database was established. Additionally, potential novel alleles were identified, providing a scientific basis for enhancing the safety of clinical blood transfusions. DNA fragments from 200 platelet donor samples in...

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Topics

Humans
Antigens, Human Platelet
High-Throughput Nucleotide Sequencing
Alleles
HLA-B Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

HLA-A Antigens

HLA-C Antigens

Gene Frequency

China

Genotype

Histocompatibility Testing

Platelet Transfusion

Blood Donors

Blood Platelets

Databases, Genetic

Source

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Identifiers

PMID: 42708771
DOI: 10.1111/tan.70851
PMCID: PMC13552256

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