Article
Simultaneous genotyping for human platelet antigen systems and HLA-A and HLA-B loci by targeted next-generation sequencing.
Frontiers in immunology - 1 Jan 2022
Wang Jielin, You Xuan, He Yanmin, Hong Xiaozhen, He Ji, Tao Sudan, Zhu Faming
Abstract excerpt
In order to treat the alloimmunization platelet transfusion refractoriness (PTR), human leukocyte antigen (HLA)-type and/or human platelet antigen (HPA)-type matched platelets between donors and patients are usually used. Therefore, genotyping of HLA-A and HLA-B loci, as well as HPA systems, for donors and patients, is of great significance. However, there is a rare report of genotyping for HLA-A and HLA-B loci...
Topics
- Humans
- Antigens, Human Platelet
- Genotype
- HLA-A Antigens
- High-Throughput Nucleotide Sequencing
- HLA-B Antigens
- Nucleotides
- Amino Acids
- RNA