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Targeted RNA-Based Oxford Nanopore Sequencing for Typing 12 Classical HLA Genes

4 Mar 2021

Abstract excerpt

Identification of human leukocyte antigen (HLA) alleles from next-generation sequencing (NGS) data is challenging because of the high polymorphism and mosaic nature of HLA genes. Owing to the complex nature of HLA genes and consequent challenges in allele assignment, Oxford Nanopore Technologies' (ONT) single-molecule sequencing technology has been of great interest due to its fitness for sequencing long reads....

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PMID: 33763116
DOI: 10.3389/fgene.2021.635601

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