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Article

Drug resistance in cancer: Principles of emergence and prevention

24 Jun 2005

Abstract excerpt

Although targeted therapy is yielding promising results in the treatment of specific cancers, drug resistance poses a problem. We develop a mathematical framework that can be used to study the principles underlying the emergence and prevention of resistance in cancers treated with targeted small-molecule drugs. We consider a stochastic dynamical system based on measurable parameters, such as the turnover rate of...

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Identifiers

PMID: 15980154
DOI: 10.1073/pnas.0501870102

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