Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies.

doi:10.1126/scitranslmed.abc7488

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies.

Science translational medicine - 27 Jan 2021

Tlemsani Camille, Takahashi Nobuyuki, Pongor Lorinc, Rajapakse Vinodh N, Tyagi Manoj, Wen Xinyu, Fasaye Grace-Ann, Schmidt Keith T, Desai Parth, Kim Chul, Rajan Arun, Swift Shannon, Sciuto Linda, Vilimas Rasa, Webb Santhana, Nichols Samantha, Figg William Douglas, Pommier Yves, Calzone Kathleen, Steinberg Seth M, Wei Jun S, Guha Udayan, Turner Clesson E, Khan Javed, Thomas Anish

Abstract excerpt

Because tobacco is a potent carcinogen, secondary causes of lung cancer are often diminished in perceived importance. To assess the extent of inherited susceptibility to small cell lung cancer (SCLC), the most lethal type of lung cancer, we sequenced germline exomes of 87 patients (77 SCLC and 10 extrapulmonary small cell) and considered 607 genes, discovering 42 deleterious variants in 35 cancer-predisposition...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to DNA Repair

Share to Exome Sequencing

Share to Germ-Line Mutation

Share to Lung Neoplasms

Share to Neoplasm Recurrence, Local

Share to Small Cell Lung Carcinoma

Source

Open in PubMed Open full text

Identifiers

PMID: 33504652
DOI: 10.1126/scitranslmed.abc7488
PMCID: PMC8489678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies.PMID 33504652Read ↗

The role of germline mutations in non-small cell lung cancer: A systematic review of emerging genetic drivers and clinical implications.Semantic proximity Read ↗

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.Semantic proximity Read ↗

Genomic features of Chinese small cell lung cancer.Semantic proximity Read ↗

Genomic Features of Chinese Small Cell Lung CancerSemantic proximity Read ↗

Next-generation sequencing reveals frequent consistent genomic alterations in small cell undifferentiated lung cancer.Semantic proximity Read ↗

An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.Semantic proximity Read ↗

Molecular subtyping of small-cell lung cancer based on mutational signatures with different genomic features and therapeutic strategies.Semantic proximity Read ↗

Rare germline deleterious variants increase susceptibility for lung cancer.Semantic proximity Read ↗

Recent progress in mapping the emerging landscape of the small-cell lung cancer genome.Semantic proximity Read ↗

Biological and therapeutic implications of the cancer-related germline mutation landscape in lung cancer.Semantic proximity Read ↗

Genomic landscape of non-small-cell lung cancer in smokers and never-smokersSemantic proximity Read ↗

Comprehensive genomic profiles of small cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.