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Article

Genes causative of primary immunodeficiency are risk factors for and are over-expressed in systemic lupus erythematosus.

Frontiers in immunology - 1 Jan 2026

Davis Haley, Owen Katherine A, Labonte Adam C, Hubbard Erika L, Kerns Sophia, Kain Jessica, Kegerreis Brian, Bachali Prathyusha, Grammer Amrie C, Lipsky Peter E

Abstract excerpt

Background: Systemic lupus erythematosus (SLE) is a polygenic autoimmune disease characterized by the production of autoantibodies leading to widespread inflammation, whereas primary immunodeficiency (PID) disease is a group of specific genetic defects in molecular pathways required for host defense to infectious agents. PID genes are found to play critical roles in development and function of the immune system,...

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Share to Databases, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lupus Erythematosus, Systemic

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Source

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Identifiers

PMID: 41929508
DOI: 10.3389/fimmu.2026.1494343
PMCID: PMC13040371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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