Contribution of genetic variants associated with primary immunodeficiencies to childhood-onset systemic lupus erythematous.

doi:10.1016/j.jaci.2022.12.807

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Article

Contribution of genetic variants associated with primary immunodeficiencies to childhood-onset systemic lupus erythematous.

The Journal of allergy and clinical immunology - 1 Apr 2023

Wu Chao-Yi, Fan Wen-Lang, Yang Huang-Yu, Chu Pi-Shuang, Liao Pei-Chun, Chen Li-Chen, Yao Tsung-Chieh, Yeh Kuo-Wei, Ou Liang-Shiou, Lin Syh-Jae, Lee Wen-I, Huang Jing-Long

Abstract excerpt

BACKGROUND: A dysregulated immune response is a hallmark of autoimmune disorders. Evidence suggests that systemic autoimmune diseases and primary immunodeficiency disorders (PIDs) may be similar diseases with different clinical phenotypes. OBJECTIVE: This study aimed to investigate the burden of PID-associated genetic variants in patients with childhood-onset systemic lupus erythematosus (cSLE). METHODS: We...

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