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Monogenic lupus: insights into disease pathogenesis and therapeutic opportunities

29 Feb 2024

Abstract excerpt

PURPOSE OF REVIEW: This review aims to provide an overview of the genes and molecular pathways involved in monogenic lupus, the implications for genome diagnosis, and the potential therapies targeting these molecular mechanisms. RECENT FINDINGS: To date, more than 30 genes have been identified as contributors to monogenic lupus. These genes are primarily related to complement deficiency, activation of the type I...

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PMID: 38420886
DOI: 10.1097/bor.0000000000001008

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