Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

African ancestry-enriched variants in the GATM gene are associated with elevated serum creatinine levels.

Genome medicine - 1 Apr 2026

Sharma Shivam, Astore Courtney A, Mariño-Ramírez Leonardo, Jordan I King

Abstract excerpt

BACKGROUND: Serum creatinine (Scr) levels are routinely used to estimate kidney function and health. Individuals of African ancestry have higher Scr levels – controlling for differences in age, sex, size, kidney function, and disease status – compared to individuals from other ancestral backgrounds. The reason for this difference is unknown. We hypothesized that there may be genetic variants found at relatively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Black People
Share to Creatinine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 41923156
DOI: 10.1186/s13073-026-01642-w
PMCID: PMC13170037

Genes

GATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

African ancestry-enriched variants in the GATM gene are associated with elevated serum creatinine levels.PMID 41923156Read ↗

African ancestry-enriched variants in the <i>GATM</i> gene are associated with elevated serum creatinine levelsSemantic proximity Read ↗

Meta-analysis of African ancestry genome-wide association studies identified novel locus and validates multiple loci associated with kidney function.Semantic proximity Read ↗

African ancestry meta-analysis of genome-wide association studies identifies a novel locus and validates multiple loci associated with kidney functionSemantic proximity Read ↗

Genetic Association and Transferability for Urinary Albumin-Creatinine Ratio as a Marker of Kidney Disease in four Sub-Saharan African Populations and non-continental Individuals of African AncestrySemantic proximity Read ↗

Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the AmericasSemantic proximity Read ↗

Refining genome-wide associated loci for serum uric acid in individuals with African ancestry.Semantic proximity Read ↗

Tractor workflow: a scalable Nextflow framework for local ancestry-aware genome-wide association studies.Semantic proximity Read ↗

KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.Semantic proximity Read ↗

Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans.Semantic proximity Read ↗

Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations.Semantic proximity Read ↗

The Association of African Ancestry and elevated creatinine in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.Semantic proximity Read ↗

KidneyGenAfrica: A multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 continental and diasporan AfricansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.