Impact of African-enriched GATM regulatory variants on creatinine-derived estimated glomerular filtration rate.

doi:10.1016/j.kint.2026.06.038

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Article

Impact of African-enriched GATM regulatory variants on creatinine-derived estimated glomerular filtration rate.

Kidney international - 1 Oct 2026

Gray Olivia A, Yerges-Armstrong Laura, Castel Stephane E, Brandenburg Jean-Tristan, Ojewunmi Oyesola, Kamiza Abram, Kalungi Allan, Hendershott Melissa C, Karim Mohd, Emde Anne-Katrin, Hamid Iman, Nguyen Khanh-Dung H, Burke Erin E, Gama Rouvick M, Mafu Trevor S, Snead Charlotte, Bramham Kate, Hansen Christian H, Nitsch Dorothea, Tomlinson Laurie, Tollman Stephen, Ramsay Michele, Naicker Saraladevi, Crampin Amelia C, Nyirenda Moffat, Kalyesubula Robert, Fatumo Segun, Fabian June

Abstract excerpt

INTRODUCTION: Serum creatinine is a commonly used biomarker for estimating glomerular filtration rate (eGFR), but is influenced by determinants unrelated to kidney function, including muscle mass, age, sex, diet, and genetic variation. Biological drivers of persistent eGFR bias in African ancestry populations remain understudied. Here, we investigated whether African-enriched genetic variation at the glycine...

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Topics

Adult
Aged
Female
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Middle Aged

Biomarkers

Black People

Creatinine

Genome-Wide Association Study

Glomerular Filtration Rate

Phenotype

Renal Insufficiency, Chronic

South Africa

Uganda

Source

Open in PubMed

Identifiers

PMID: 42498056
DOI: 10.1016/j.kint.2026.06.038

Genes

GATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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