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Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans.

Human molecular genetics - 28 Jul 2021

Fatumo Segun, Chikowore Tinashe, Kalyesubula Robert, Nsubuga Rebecca N, Asiki Gershim, Nashiru Oyekanmi, Seeley Janet, Crampin Amelia C, Nitsch Dorothea, Smeeth Liam, Kaleebu Pontiano, Burgess Stephen, Nyirenda Moffat, Franceschini Nora, Morris Andrew P, Tomlinson Laurie, Newton Robert

Abstract excerpt

Genome-wide association studies (GWAS) of kidney function have uncovered hundreds of loci, primarily in populations of European ancestry. We have undertaken the first continental African GWAS of estimated glomerular filtration rate (eGFR), a measure of kidney function used to define chronic kidney disease (CKD). We conducted GWAS of eGFR in 3288 East Africans from the Uganda General Population Cohort (GPC) and...

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PMID: 33783510
DOI: 10.1093/hmg/ddab088
PMCID: PMC8330895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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