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Article

Tractor workflow: a scalable Nextflow framework for local ancestry-aware genome-wide association studies.

Bioinformatics (Oxford, England) - 3 May 2026

Shah Nirav N, Tan Taotao, Honorato-Mauer Jessica, Lin Yi-Sian, Maihofer Adam X, Zai Clement C, Santoro Marcos, Nievergelt Caroline M, Atkinson Elizabeth G

Abstract excerpt

MOTIVATION: The routine exclusion of admixed individuals from traditional genome-wide association studies (GWAS) due to concerns about spurious associations has limited multi-ancestry genetic discovery. Tractor addresses this issue by incorporating local ancestry into association testing, enabling the identification of ancestry-enriched signals and generating ancestry-specific summary statistics. However,...

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PMID: 41838407
DOI: 10.1093/bioinformatics/btag124
PMCID: PMC13197121

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