Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

African-specific variants at the GATM locus and genetic bias in creatinine-based GFR estimation.

Kidney international - 1 Oct 2026

Khan Atlas, Kiryluk Krzysztof

Abstract excerpt

Serum creatinine-based estimated glomerular filtration rate is widely used to assess kidney function but is influenced by nonrenal determinants of creatinine production. The recent identification of an African ancestry-specific glycine amidinotransferase variant that increases creatine synthesis and serum creatinine without affecting measured kidney function provides a biological explanation for part of the...

Read the complete abstract on PubMed

Topics

Humans
Glomerular Filtration Rate
Creatinine
Amidinotransferases
Black People
African People
Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 42760020
DOI: 10.1016/j.kint.2026.06.049

Genes

GATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

African-specific variants at the GATM locus and genetic bias in creatinine-based GFR estimation.PMID 42760020Read ↗

Impact of African-enriched GATM regulatory variants on creatinine-derived estimated glomerular filtration rate.Semantic proximity Read ↗

African ancestry-enriched variants in the GATM gene are associated with elevated serum creatinine levels.Semantic proximity Read ↗

African ancestry-enriched variants in the <i>GATM</i> gene are associated with elevated serum creatinine levelsSemantic proximity Read ↗

Association between GATM gene polymorphism and progression of chronic kidney disease: a mitochondrial related genome-wide Mendelian randomization study.Semantic proximity Read ↗

Genetic diversity and natural selection footprints of the glycine amidinotransferase gene in various human populations.Semantic proximity Read ↗

Genetic Association and Transferability for Urinary Albumin-Creatinine Ratio as a Marker of Kidney Disease in four Sub-Saharan African Populations and non-continental Individuals of African AncestrySemantic proximity Read ↗

Polymorphism in the GATM Locus Associated with Dialysis-Independent Chronic Kidney Disease but Not Dialysis-Dependent Kidney Failure.Semantic proximity Read ↗

The Association of African Ancestry and elevated creatinine in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.Semantic proximity Read ↗

Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure.Semantic proximity Read ↗

Solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney.Semantic proximity Read ↗

Do genetic variations in proximal tubule transporters influence tenofovir-induced renal dysfunction? An exploratory study in a Ghanaian population.Semantic proximity Read ↗

Determinants of early change in serum creatinine after initiation of dolutegravir-based antiretroviral therapy in South Africa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.