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Article

Genetic evidence for causal relationship between general cognition and treatment resistance in schizophrenia.

Translational psychiatry - 1 Apr 2026

Li Chao, Zhong Yuanxin, Sham Pak Chung, Chan Sherry Kit Wa

Abstract excerpt

Treatment-resistant schizophrenia (TRS) is characterized by symptoms unresponsive to standard antipsychotics, possibly representing a distinct subtype of schizophrenia with unique neurobiological mechanisms. TRS may share neurodevelopmental mechanisms with cognitive impairment, which is also frequently resistant to treatment. However, the association between TRS and cognitive impairment remains inconclusive in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41922311
DOI: 10.1038/s41398-026-03994-8
PMCID: PMC13043664

Genes

TMX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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