Article

Genome-Wide Association Study of Coronary Microvascular Disease assessed by cardiac perfusion Positron Emission Tomography converges on NF-кB pathway

2025-03-21

Abstract excerpt

<h4>Background</h4> Coronary Microvascular Disease (CMVD) contributes to the large burden of ischemic heart disease, and there is a need for mechanistic insight and targeted therapies. Perfusion cardiac PET allows for the quantitative assessment of myocardial blood flow reserve (MBFR), which reflects coronary microvascular function. Here we perform the first genome-wide association study (GWAS) using cardiac PET M...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3bb4b550-5a57-559c-80ec-fdc0d1cec731
DOI: 10.1101/2025.03.20.25324357

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-Wide Association Study of Coronary Microvascular Disease assessed by cardiac perfusion Positron Emission Tomography converges on NF-кB pathwayDOI 10.1101/2025.03.20.25324357Read

Genome-wide association study of coronary flow reserve assessed by cardiac perfusion PET suggests a role for NF-κB pathway.Semantic proximity Read

Integrating Imaging-Derived Clinical Endotypes with Plasma Proteomics and External Polygenic Risk Scores Enhances Coronary Microvascular Disease Risk Prediction<sup>†</sup>Semantic proximity Read

Integrating Imaging-Derived Clinical Endotypes with Plasma Proteomics and External Polygenic Risk Scores Enhances Coronary Microvascular Disease Risk Prediction.Semantic proximity Read

Friend of GATA2 Variant Ser657Gly Is Associated With Coronary Microvascular Disease.Semantic proximity Read

Genetic Insights Into Coronary Microvascular DiseaseSemantic proximity Read

FOG2 coding variant Ser657Gly is associated with Coronary Microvascular Disease through altered hypoxia-mediated gene transcriptionSemantic proximity Read

Large-Scale Identification of Novel Protein Biomarkers and Therapeutic Targets in Heart and Brain DiseaseSemantic proximity Read

Identifying Potential Drug Targets in Coronary Atherosclerosis: Insights from the Druggable Genome and Mendelian Randomization.Semantic proximity Read

Large-scale identification of protein biomarkers and therapeutic targets in heart and brain disease.Semantic proximity Read

Proteome-wide Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiometabolic diseases and longevitySemantic proximity Read

Deep Learning Enables Genome-Wide Association Studies of Microvascular FeaturesSemantic proximity Read

Single cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1 <sup>+</sup> Macrophage ActivationSemantic proximity Read