Article

Cardiovascular Disease-Associated Non-Coding Variants Disrupt GATA4-DNA Binding and Regulatory Functions

2024-09-24

Abstract excerpt

Genome-wide association studies have mapped over 90% of cardiovascular disease (CVD)-associated variants within the non-coding genome. Non-coding variants in regulatory regions of the genome, such as promoters, enhancers, silencers, and insulators, can alter the function of tissue-specific transcription factors (TFs) proteins and their gene regulatory function. In this work, we used a computational approach to ide...

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Literature Corpus work: 17014036-4b3d-5c67-8be6-f750a901e579
DOI: 10.1101/2024.09.19.613959

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