Article
Genome-wide association study of coronary flow reserve assessed by cardiac perfusion PET suggests a role for NF-κB pathway.
Nature cardiovascular research - 1 Jun 2026
Venkatesh Rasika, Cherlin Tess, Wayne Nicole, Kumar Rachit, Guare Lindsay, Singamneni Venkata P, Irving Brett, Dudek Scott, Levin Michael G, Setia-Verma Shefali, Guerraty Marie A
Abstract excerpt
Coronary microvascular disease (CMVD) contributes to the large burden of ischemic heart disease (IHD), and there is a need for mechanistic insight and targeted therapies. Perfusion cardiac PET allows for the quantitative assessment of coronary flow reserve (CFR), which reflects coronary microvascular function. Here we use cardiac PET CFR as a measure of CMVD to perform first a gene association study with...
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