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Article

Triglyceride-glucose index, genetic predisposition, and incident depression: a prospective cohort study from the UK Biobank.

Psychological medicine - 1 Apr 2026

Hu Wei, Liu Tian-Shu, Shen Zhen-Zhen, Tian Ge, Jia Cun-Xian, Liu Bao-Peng

Abstract excerpt

BACKGROUND: The triglyceride-glucose (TyG) index, a surrogate marker for insulin resistance, has been associated with depressive symptoms, but findings are inconsistent and predominantly based on cross-sectional studies. This study investigated whether the TyG index is associated with incident depression independent of genetic predisposition and explored potential risk factors underlying this association....

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Identifiers

PMID: 41918219
DOI: 10.1017/S0033291726103535
PMCID: PMC13079221

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