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Article

Polygenic risk score, healthy lifestyles, and risk of incident depression.

Translational psychiatry - 29 Mar 2021

Cao Zhi, Yang Hongxi, Ye Yixuan, Zhang Yuan, Li Shu, Zhao Hongyu, Wang Yaogang

Abstract excerpt

Genetic factors increase the risk of depression, but the extent to which this can be offset by modifiable lifestyle factors is unknown. We investigated whether a combination of healthy lifestyles is associated with lower risk of depression regardless of genetic risk. Data were obtained from the UK Biobank and consisted of 339,767 participants (37-73 years old) without depression between 2006 and 2010. Genetic...

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Identifiers

PMID: 33782378
DOI: 10.1038/s41398-021-01306-w
PMCID: PMC8007584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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