Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational and gene fusion analyses of primary large cell and large cell neuroendocrine lung cancer.

Oncotarget - 8 Sept 2015

Karlsson Anna, Brunnström Hans, Lindquist Kajsa Ericson, Jirström Karin, Jönsson Mats, Rosengren Frida, Reuterswärd Christel, Cirenajwis Helena, Borg Åke, Jönsson Per, Planck Maria, Jönsson Göran, Staaf Johan

Abstract excerpt

Large cell carcinoma with or without neuroendocrine features (LCNEC and LC, respectively) constitutes 3-9% of non-small cell lung cancer but is poorly characterized at the molecular level. Herein we analyzed 41 LC and 32 LCNEC (including 15 previously reported cases) tumors using massive parallel sequencing for mutations in 26 cancer-related genes and gene fusions in ALK, RET, and ROS1. LC patients were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Carcinoma, Large Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Cohort Studies

Share to Gene Fusion

Share to Lung Neoplasms

Share to Neuroendocrine Tumors

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 26124082
DOI: 10.18632/oncotarget.4314
PMCID: PMC4673143

Genes

ALK
RET
ROS1
KRAS
MET
PTEN
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational and gene fusion analyses of primary large cell and large cell neuroendocrine lung cancer.PMID 26124082Read ↗

Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.Semantic proximity Read ↗

Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung.Semantic proximity Read ↗

Molecular Pathology of Pulmonary Large Cell Neuroendocrine Carcinoma: Novel Concepts and TreatmentsSemantic proximity Read ↗

The Unmet Diagnostic and Treatment Needs in Large Cell Neuroendocrine Carcinoma of the LungSemantic proximity Read ↗

Large cell carcinoma of the lung: clinically oriented classification integrating immunohistochemistry and molecular biology.Semantic proximity Read ↗

Next-Generation Sequencing of a Cohort of Pulmonary Large Cell Carcinomas Reclassified by World Health Organization 2015 Criteria.Semantic proximity Read ↗

Integrated Molecular and Clinical Characterization of Pulmonary Large Cell Neuroendocrine CarcinomaSemantic proximity Read ↗

Identification of Actionable Gene Variants in Pulmonary Large-Cell Neuroendocrine Carcinoma: A Real-World Analysis of a Polish Cohort.Semantic proximity Read ↗

Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group.Semantic proximity Read ↗

Comparison of genomic landscapes of large cell neuroendocrine carcinoma, small cell lung carcinoma, and large cell carcinomaSemantic proximity Read ↗

Beyond Traditional Morphological Characterization of Lung Neuroendocrine Neoplasms: In Silico Study of Next-Generation Sequencing Mutations Analysis across the Four World Health Organization Defined GroupsSemantic proximity Read ↗

Prevalence of TP-53/Rb-1 Co-Mutation in Large Cell Neuroendocrine CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.