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Article

Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2017

Miyoshi Tomohiro, Umemura Shigeki, Matsumura Yuki, Mimaki Sachiyo, Tada Satoshi, Makinoshima Hideki, Ishii Genichiro, Udagawa Hibiki, Matsumoto Shingo, Yoh Kiyotaka, Niho Seiji, Ohmatsu Hironobu, Aokage Keiju, Hishida Tomoyuki, Yoshida Junji, Nagai Kanji, Goto Koichi, Tsuboi Masahiro, Tsuchihara Katsuya

Abstract excerpt

PURPOSE: Although large-cell neuroendocrine carcinoma (LCNEC) of the lung shares many clinical characteristics with small-cell lung cancer (SCLC), little is known about its molecular features. We analyzed lung LCNECs to identify biologically relevant genomic alterations. EXPERIMENTAL DESIGN: We performed targeted capture sequencing of all the coding exons of 244 cancer-related genes on 78 LCNEC samples [65...

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Source

Identifiers

PMID: 27507618
DOI: 10.1158/1078-0432.CCR-16-0355

Genes

AKT2
EGFR
ERBB2
FGFR1
HRAS
KIT
KRAS
PTEN
RICTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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