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Article

Implication of cytoplasmic p53 expression in pulmonary neuroendocrine carcinoma using next-generation sequencing analysis.

Histopathology - 1 Jan 2024

Jimbo Naoe, Ohbayashi Chiho, Fujii Tomomi, Takeda Maiko, Mitsui Suguru, Tsukamoto Ryuko, Tanaka Yugo, Itoh Tomoo, Maniwa Yoshimasa

Abstract excerpt

AIMS: Cytoplasmic p53 expression indicates a high frequency of TP53 abnormalities in gynaecological carcinoma. However, the implication of this expression in pulmonary neuroendocrine carcinoma (NEC) remains unclear. Thus, our study aimed to fill this research gap. METHODS AND RESULTS: Immunohistochemistry (IHC) of p53 was performed on 146 cases of resected small-cell lung carcinoma and large-cell NEC, and...

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Identifiers

PMID: 37814580
DOI: 10.1111/his.15059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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