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Article

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 2008

Yun Chi, Stanhill Ariel, Yang Yun, Zhang Yuhong, Haynes Cole M, Xu Chong-Feng, Neubert Thomas A, Mor Adam, Philips Mark R, Ron David

Abstract excerpt

The burden of protein misfolding is believed to contribute to aging. However, the links between adaptations to conditions associated with protein misfolding and resistance to the time-dependent attrition of cellular function remain poorly understood. We report that worms lacking aip-1, a homologue of mammalian AIRAP (arsenic-inducible proteasomal 19S regulatory particle-associated protein), are not only impaired...

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Identifiers

PMID: 18467495
DOI: 10.1073/pnas.0707025105
PMCID: PMC2383958

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AIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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