Article
Caspase-1 Variants and Plasma IL-1β in Patients with Leishmania guyanensis Cutaneous Leishmaniasis in the Amazonas.
International journal of molecular sciences - 19 Nov 2024
de Souza Josué Lacerda, de Farias Guerra Marcus Vinitius, de Mesquita Tirza Gabrielle Ramos, Junior José do Espírito Santo, Sequera Hector David Graterol, da Silva Lener Santos, da Silva Larissa Almeida, Moura Filipe Menezes, Menescal Lizandra Stephanny Fernandes, da Costa Torres Júlia, Pinheiro Suzana Kanawati, Kerr Herllon Karllos Athaydes, Ogusku Mauricio Morishi, de Souza Mara Lúcia Gomes, de Moura Neto Jose Pereira, Sadahiro Aya, Ramasawmy Rajendranath
Abstract excerpt
Leishmaniasis, a disease caused by protozoan Leishmania spp., exhibits a broad range of clinical manifestations. Host resistance or susceptibility to infections is often influenced by the genetic make-up associated with natural immunity. Caspase-1, a key component of the NLRP3 inflammasome, is critical for processing pro-IL-1β into its active form, IL-1β, while CARD8 functions as an NLRP3 inflammasome inhibitor....
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