Article
Variants of MIRNA146A rs2910164 and MIRNA499 rs3746444 are associated with the development of cutaneous leishmaniasis caused by Leishmania guyanensis and with plasma chemokine IL-8.
PLoS neglected tropical diseases - 1 Sept 2021
de Mesquita Tirza Gabrielle Ramos, Junior José do Espírito Santo, de Lacerda Thais Carneiro, Queiroz Krys Layane Guimarães Duarte, Júnior Cláudio Marcello da Silveira, Neto José Pereira de Moura, Gomes Lissianne Augusta Matos, de Souza Mara Lúcia Gomes, Guerra Marcus Vinitius de Farias, Ramasawmy Rajendranath
Abstract excerpt
Leishmania are intracellular protozoan parasites that cause a wide spectrum of clinical manifestations in genetically susceptible individuals with an insufficient or balanced Th1 immune response to eliminate the parasite. MiRNAs play important regulatory role in numerous biological processes including essential cellular functions. miR146-a acts as an inhibitor of interleukin 1 receptor associated kinase 1 (IRAK1)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.