Article
Variants of CARD8 in Leishmania guyanensis-cutaneous leishmaniasis and influence of the variants genotypes on circulating plasma cytokines IL-1β, TNFα and IL-8.
PLoS neglected tropical diseases - 1 Jun 2023
Sequera Héctor David Graterol, Souza Josué Lacerda de, Junior José do Espírito Santo, Silva Lener Santos da, Pinheiro Suzana Kanawati, Kerr Herllon Karllos Athaydes, Souza Mara Lúcia Gomes de, Guerra Marcus Vinitius de Farias, Mesquita Tirza Gabrielle Ramos de, Ramasawmy Rajendranath
Abstract excerpt
Nucleotide-binding oligomerization domain, leucine-rich repeat-containing protein family (NLR) are intracellular pathogen recognition receptors mediating innate immunity, releasing proinflammatory cytokines IL-1β and IL-18, and promoting pyroptotic cell death, upon sensing pathogenic or endogenous danger signals. In animal models, NLRP3 inflammasome has a dual role, pathogenic or protective in...
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