Article
A CRISPR/dCas9 mediated electrochemical impedimetric biosensor for sensitive mtDNA detection.
Analytica chimica acta - 1 Jun 2026
Chen Fei, Huang Mengqin, Zeng Shu, Wan Yi, Qin Anjun, Yang Xinzhe, Fu Danfeng, Negahdary Masoud, Zhang Chenghui
Abstract excerpt
BACKGROUND: The accumulation of mitochondrial DNA (mtDNA) mutations in cells is closely linked to various human diseases. Detection of single-nucleotide variation (SNV) in mtDNA plays a crucial role in understanding the heteroplasmy of mtDNAs that contain pathogenic changes. While conventional nu...
Topics
- DNA, Mitochondrial
- Biosensing Techniques
- Humans
- CRISPR-Cas Systems
- Electrochemical Techniques
- Limit of Detection
- Polymorphism, Single Nucleotide
- Electrodes
- Silver
- Metal Nanoparticles
- Tin Compounds
- Polyethyleneimine