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A CRISPR/dCas9 mediated electrochemical impedimetric biosensor for sensitive mtDNA detection.

Analytica chimica acta - 1 Jun 2026

Chen Fei, Huang Mengqin, Zeng Shu, Wan Yi, Qin Anjun, Yang Xinzhe, Fu Danfeng, Negahdary Masoud, Zhang Chenghui

Abstract excerpt

BACKGROUND: The accumulation of mitochondrial DNA (mtDNA) mutations in cells is closely linked to various human diseases. Detection of single-nucleotide variation (SNV) in mtDNA plays a crucial role in understanding the heteroplasmy of mtDNAs that contain pathogenic changes. While conventional nucleic acid sequencing-based methods are instrumental and complex, which hampered their capability in revealing the...

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PMID: 41903969
DOI: 10.1016/j.aca.2026.345323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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