Quantifying Cellular Pluripotency and Pathway Robustness through Forman-Ricci Curvature

Abstract excerpt

In stem cell biology, cellular pluripotency describes the capacity of a given cell to differentiate into multiple cell types. From a statistical physics perspective, entropy provides a statistical measure of randomness and has been demonstrated as a way to quantitate pluripotency when considering biological gene networks. Furthermore, recent theoretical work has established a relationship between Ricci curvature (...

Topics

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• Algorithms
• Phenotype
• Single-Cell Analysis
• Single-Cell Gene Expression Analysis

Identifiers and source

Literature Corpus work

0b6c5dd9-bb99-5b51-abfb-faefbbe709c4

DOI

10.1101/2021.10.03.462918