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Article

Viral Escape from a Candidate HIV-1 Vaccine Targeting Protease Cleavage Sites Is Associated with a Dramatic Fitness Loss in SIVmac239-Infected Cynomolgus Macaques.

Viruses - 17 Mar 2026

Lim So-Yon, Luo Ma, Whitney James B

Abstract excerpt

A novel HIV-1 vaccine candidate under development targeting the highly conserved protease cleavage regions reduced viral acquisition and delayed disease progression in a macaque SIV-challenge model. Breakthrough virus isolated from vaccinees and control animals were sequenced in the regions surrounding the SIV protease cleavages. We identified unique viral mutations that were associated with alterations in viral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41902278
DOI: 10.3390/v18030370
PMCID: PMC13030808

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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