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Measuring Alphavirus Fidelity Using Non-Infectious Virus Particles.

Viruses - 15 May 2020

Patterson Edward I, Khanipov Kamil, Swetnam Daniele M, Walsdorf Samantha, Kautz Tiffany F, Thangamani Saravanan, Fofanov Yuriy, Forrester Naomi L

Abstract excerpt

Mutations are incorporated into the genomes of RNA viruses at an optimal frequency and altering this precise frequency has been proposed as a strategy to create live-attenuated vaccines. However, determining the effect of specific mutations that alter fidelity has been difficult because of the rapid selection of the virus population during replication. By deleting residues of the structural polyprotein PE2...

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Identifiers

PMID: 32429270
DOI: 10.3390/v12050546
PMCID: PMC7291308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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