Article
Immunogenicity of sequences around HIV-1 protease cleavage sites: potential targets and population coverage analysis for a HIV vaccine targeting protease cleavage sites.
Vaccine - 24 Jun 2013
Luo Ma, Capina Rupert, Daniuk Christina, Tuff Jeff, Peters Harold, Kimani Makubo, Wachihi Charles, Kimani Joshua, Ball Terry Blake, Plummer Francis A
Abstract excerpt
Developing an effective preventative vaccine against HIV-1 has proved to be a great challenge. The classical and proven vaccine approach has failed so far or produced a modest effect, new approaches are needed. In this study we evaluated the immunogenicity of the sequences around the protease cleavage sites (PCS) and the population coverage of a vaccine targeting HIV-1 PCS. The sequence conservation was evaluated...
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