Reversing neuroinflammation in ischemic stroke through efferocytotic phenotype reprogramming with polymeric nanoparticles.

Abstract excerpt

Ischemic stroke therapy remains challenging due to a detrimental post-reperfusion inflammatory cascade that exacerbates neuronal damage, a process critically mediated by neutrophils and microglia. Neutrophils infiltrate the brain to release pro-inflammatory factors and neutrophil extracellular traps (NETs), while microglia become activated and amplify neuroinflammation. However, both cell types possess phenotypic...

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