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Article

Custom-Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia.

Angewandte Chemie (International ed. in English) - 14 May 2018

Zeng Feng, Wu Yingwei, Li Xinwei, Ge Xiaojiao, Guo Qinghua, Lou Xiaobing, Cao Zhonglian, Hu Bingwen, Long Nicholas J, Mao Ying, Li Cong

Abstract excerpt

The neuroprotective effect of ceria nanoparticles in the context of brain disorders has been explained by their antioxidant effect. However, the in-depth mechanism remains unknown. As resident immune cells in the brain, microglia exert a variety of functional reprogramming termed as polarization in response to stress stimuli. Herein, custom-made ceria nanoparticles were developed and found to scavenge multiple...

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PMID: 29575461
DOI: 10.1002/anie.201802309

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