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Article

A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH-related proteins 1-5 in human plasma.

Proteomics - 1 Mar 2017

Zhang Pingbo, Zhu Min, Geng-Spyropoulos Minghui, Shardell Michelle, Gonzalez-Freire Marta, Gudnason Vilmundur, Eiriksdottir Gudny, Schaumberg Debra, Van Eyk Jennifer E, Ferrucci Luigi, Semba Richard D

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of visual loss among older adults. Two variants in the complement factor H (CFH) gene, Y402H and I62V, are strongly associated with risk of AMD. CFH is encoded in regulator of complement activation gene cluster in chromosome 1q32, which includes complement factor related (CFHR) proteins, CFHR1 to CFHR5, with high amino acid sequence homology to CFH. Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27647805
DOI: 10.1002/pmic.201600237
PMCID: PMC5534329

Genes

CFH
CFHR1
SRM
CFHR5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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