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Article

A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes.

Proteomics - 1 Aug 2017

Semba Richard D, Zhang Pingbo, Zhu Min, Fabbri Elisa, Gonzalez-Freire Marta, Moaddel Ruin, Geng-Spyropoulos Minghui, Ferrucci Luigi

Abstract excerpt

Circulating polypeptides and proteins have been implicated in reversing or accelerating aging phenotypes, including growth/differentiation factor 8 (GDF8), GDF11, eotaxin, and oxytocin. These proteoforms, which are defined as the protein products arising from a single gene due to alternative splicing and PTMs, have been challenging to study. Both GDF8 and GDF11 have known antagonists such as follistatin (FST),...

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Source

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Identifiers

PMID: 28508553
DOI: 10.1002/pmic.201600232
PMCID: PMC5863538

Genes

GDF11
FST
SRM
WFIKKN1
WFIKKN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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