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Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2005

Wjst Matthias, van den Boom Dirk

Abstract excerpt

Major strengths of mass spectrometry analysis include the accuracy of the detection principle and the automatic data storage, making it a premier choice for high-throughput single-nucleotide polymorphism genotyping. We explain the assay principle in detail and give step-by-step laboratory instructions. Finally, references point toward further use of mass spectrometry analysis for molecular haplotyping, pooled DNA...

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Automation
Genotype
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16100404
DOI: 10.1385/1-59259-957-5:125

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