Article

Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia

2024-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Focal Cortical Dysplasia (FCD) is a neurodevelopmental condition characterized by malformations of the cerebral cortex that often cause drug-resistant epilepsy. In this study, we performed multi-omics single-cell profiling to map the chromatin accessibility and transcriptome landscapes of FCD type II, generating a comprehensive multimodal single-cell dataset comprising 61,525 cells from 11 clini...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8ac7874-e738-55a2-a7df-977f0ca06077
DOI: 10.1101/2024.05.29.596419

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasiaDOI 10.1101/2024.05.29.596419Read

Identifying cellular markers of focal cortical dysplasia type II with cell-type deconvolution and single-cell signaturesSemantic proximity Read

Somatic Mosaicism Patterns Define Clinical-Surgical Subtypes of Focal Cortical Dysplasia Through Cell-Type-Specific ExpressionSemantic proximity Read

Identifying cellular markers of focal cortical dysplasia type II with cell-type deconvolution and single-cell signaturesSemantic proximity Read

Single-cell genotyping and transcriptomic profiling in focal cortical dysplasiaSemantic proximity Read

Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia.Semantic proximity Read

Focal cortical dysplasia type II: review of neuropathological manifestations and pathogenetic mechanismsSemantic proximity Read

Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single-nucleus multiomicsSemantic proximity Read

Transcriptome analyses of the cortex and white matter of focal cortical dysplasia type II: insights into disease mechanisms and tissue characterizationSemantic proximity Read

Identification of pericyte loss and neutrophils infiltration in Focal cortical dysplasia by Integrated Analysis of Single-Cell and Bulk RNA-SequencingSemantic proximity Read

Comprehensive multiomic profiling of somatic mutations in malformations of cortical developmentSemantic proximity Read

The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3DSemantic proximity Read

Genomic DNA methylation distinguishes subtypes of human focal cortical dysplasiaSemantic proximity Read