BrainEnrich: Revealing Biological Insights for Imaging-Derived Phenotypes Through Transcriptomic Enrichment.

Abstract excerpt

While the field of imaging transcriptomics is evolving rapidly, several methodological challenges persist in functional enrichment analysis. Here, we introduce BrainEnrich, an R package that integrates whole-brain gene expression profiles from the Allen Human Brain Atlas (AHBA) with in vivo imaging-derived phenotypes (IDPs). By offering a suite of flexible association methods, aggregation strategies,...

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• Brain
• Gene Expression Profiling
• Major Depressive Disorder
• Neuroimaging
• Phenotype