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Article

The birth, death, and evolutionary compensation of uORFs in Drosophila.

Nucleic acids research - 19 Mar 2026

Xu Mengze, Liu Chenlu, Jin Wanting, Sun Yuanqiang, Duan Yuange, Tang Xiaolu, Lu Jian

Abstract excerpt

Upstream open reading frames (uORFs) are critical regulators of messenger RNA translation, yet their evolutionary dynamics remain poorly understood. Here, we analyze uORF evolution across Drosophila species and uncover pervasive birth-death turnover. This process is characterized by a persistent excess of upstream start codon (uATG) gains over losses, shaped by the interplay of mutational input and natural...

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Identifiers

PMID: 41885210
DOI: 10.1093/nar/gkag275
PMCID: PMC13019311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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