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Polygenic Risk Score Predicts Prostate Cancer Risk Independent of Type 2 Diabetes.

Diabetes, obesity & metabolism - 1 Jun 2026

Lee Guk Jin, Jung Sang-Hyuk, Lee Jonghyun, Moon Ki Won, Yun Jae-Seung, Kim Dokyoon

Abstract excerpt

AIMS: Type 2 diabetes mellitus (T2DM) has been inversely associated with prostate cancer (PrCa) risk. However, it remains unclear whether a polygenic risk score (PRS) for PrCa can effectively stratify risk among men with T2DM. The primary objective of this study was to assess whether a PrCa PRS predicts PrCa risk independently of T2DM status. The secondary objective was to evaluate potential mediating factors,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41883289
DOI: 10.1111/dom.70690
PMCID: PMC13146153

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