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Article

Prostate Cancer, Genetic Susceptibility, and Risk of Chronic Non-Urological Complications.

The Prostate - 1 Jun 2026

Helfand Brian T, Shi Zhuqing, Mulford Ashley J, Tran Huy, Wei Jun, Ashworth Annabelle, Zheng S Lilly, Sanders Alan R, Graham Nathan, Cabral Joshua, Lu Jim, Beebe-Dimmer Jennifer L, Cooney Kathleen A, Duggan David, Xu Jianfeng

Abstract excerpt

BACKGROUND: Chronic nonurological complications are common among prostate cancer (PCa) survivors; however, their spectrum, magnitude, and genetic contribution remain poorly characterized. METHODS: We evaluated 15 commonly reported nonurological complications and tested their associations with exposure to PCa and disease-specific polygenic risk scores (PRS) in the UK Biobank (UKB; N = 219,133). Analyses were...

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Identifiers

PMID: 42053416
DOI: 10.1002/pros.70190
PMCID: PMC13172947

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