Lung gene expression and single cell analyses reveal two subsets of idiopathic pulmonary fibrosis (IPF) patients associated with different pathogenic mechanisms

Abstract excerpt

Idiopathic pulmonary fibrosis is a progressive and debilitating lung disease with large unmet medical need and few treatment options. We describe an analysis connecting single cell gene expression with bulk gene expression-based subsetting of patient cohorts to identify IPF patient subsets with different underlying pathogenesis and cellular changes. We reproduced earlier findings indicating the existence of two...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to IL-33, ST2, and ILC Pathways
• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Share to Sarcoidosis and Beryllium Toxicity Research